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Sexually Transmitted Infections, especially Herpes II, and Prostate Cancer among Men in the U.S. Military
a
statistically significant association between prostate cancer and
serologic evidence of HSV-2 infection was detected in the earlier sample (odds ratio, 1.60; 95% confidence interval, 1.05-2.44).
The strength of this association increased when analyses were restricted to sera collected at least 60 months before diagnosis (odds ratio, 2.04; 95% confidence interval, 1.26-3.29; 204 pairs).
If
this association is causal, then our findings would suggest a long
latency period for prostate cancer development after HSV-2 infection...
Abstract
Studies of self-reported sexually transmitted infections (STI)
suggesting an association with prostate cancer may reflect
underreporting of such infections among nondiseased subjects. To reduce
such bias, we studied archived sera in a cohort of U.S. military
personnel known to have high rates of both STIs and prostate cancer.
Using a nested case-control design, serum samples from 534 men who
served on active duty between September 1, 1993 and September 1, 2003
were examined. Controls were individually matched to cases based on
date of serum collection, date of birth, branch of service, military
rank, marital status, and race. Each of the 267 case-control pairs had
two serum samples: a recent serum sample, taken ∼1 year before the
case's prostate cancer diagnosis, and an earlier serum sample, taken ∼8
years before diagnosis. Each serum specimen was studied for antibodies
against human papillomavirus, herpes simplex virus-2 (HSV-2), and
Chlamydia trachomatis. Logistic regression accounted for matching and
potential confounding factors.
Study
data indicated no association between prostate cancer and serologic
evidence of infections just before the reference date.
However, a
statistically significant association between prostate cancer and
serologic evidence of HSV-2 infection was detected in the earlier sample (odds ratio, 1.60; 95% confidence interval, 1.05-2.44).
The strength of this association increased when analyses were restricted to sera collected at least 60 months before diagnosis (odds ratio, 2.04; 95% confidence interval, 1.26-3.29; 204 pairs).
If
this association is causal, then our findings would suggest a long
latency period for prostate cancer development after HSV-2 infection. (Cancer Epidemiol Biomarkers Prev 2009;18(10):2665–71)
http://cebp.aacrjournals.org/content/18/10/2665.abstract
1. Leslie K. Dennis1,
2. Julie A. Coughlin1,
3. Brittany C. McKinnon1,
4. Timothy S. Wells2,
5. Charlotte A. Gaydos3,
6. Eva Hamsikova4 and
7. Gregory C. Gray1
1Department of Epidemiology, College of Public Health, University
of Iowa, Iowa City, Iowa; 2Air Force Research Laboratory,
Wright-Patterson Air Force Base, Dayton, Ohio; 3Division of Infectious
Diseases, Johns Hopkins University, Baltimore, Maryland; and
4Department of Experimental Virology, Institute of Hematology and Blood
Transfusion, Prague, Czech Republic
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