Vaccines

HPV Vaccines Do Not Cover Most Common HPV Types in Black Women (4/2014)

Vaccines Do Not Cover Most Common HPV Types in Black Women

Advice to Clinicians: Look Beyond HPV 16 and HPV 18
October 28, 2013, Nick Mulcahy,
The HPV subtypes that are most common in black women in the United States are not targeted by the currently available vaccines Gardasil and Cervarix, according to new research.

The findings suggest that current HPV vaccination will be less beneficial for black women in the US than for their white counterparts, said study coauthor Catherine Hoyo, PhD, MPH, of Duke University, in Durham, North Carolina.

She spoke at a press briefing today [28 Oct 2013] at the annual International Conference on Frontiers in Cancer Prevention Research, in National Harbor, Maryland. The meeting is sponsored by the American Association for Cancer Research.

“The approved cervical cancer vaccines are effective but may not be effective for everyone,” said Paul Limburg, MD, from the Mayo Clinic, in Rochester, Minnesota, who moderated the press briefing. He was not involved with the study.

Persistent infection with HPV 16 and/or HPV 18 accounts for about 70% of all cervical cancers, said Dr. Hoyo. These are the subtypes targeted by Gardasil and Cervarix. Gardasil also targets HPV 6 and HPV 11.

Some black women in the new study did, in fact, have infections with HPV 16 and/or HPV 18. But much less often — their rate was about half of that of white women.

“Since African-American women don’t seem to be getting the same subtypes of HPV with the same frequency, the vaccines aren’t helping all women equally,” said study coauthor Adriana Vidal, PhD, in a press statement. She is also from Duke University.

The investigators prospectively looked at 572 women at 10 Duke-affiliated clinics with abnormal Pap tests who then underwent colposcopy; the group was about evenly divided among blacks (n = 280) and whites (n = 292). And just about even numbers of the respective racial groups subsequently had evidence of cervical intraepithelial neoplasia 1 (CIN1; 112 vs 118).

For whites with CIN1, the most frequent HPV subtypes were 16, 18, 56, 39, and 66.

But for blacks with CIN1, the most frequent HPV subtypes were 33, 35, 58, and 68.

Thus, in blacks, the most common genotypes were not HPV 16 and 18, which defies conventional wisdom about HPV infection.

There were no data on Hispanics in the new presentation because their numbers were too small at this point to be included, said Dr. Hoyo.

Without HPV 16/18, Are Some Black Women “Getting Dropped”?

The study findings may help explain why black women in the US are harder hit by cervical cancer than white women, said Dr. Hoyo.

She pointed out that both the incidence of invasive cervical cancer and related mortality rates are higher in blacks than in whites.
“We don’t know what is causing the disparity,” Dr. Hoyo told Medscape Medical News in a phone interview after the press conference.

“The problem is not likely detection,” she said, explaining that screening rates for precancerous lesions are comparable for black and white women.

The new data, however, suggest that, if clinicians are strongly focusing on HPV 16 and 18 for more careful follow-up in their black patients, then they may be missing some eventual cervical cancers, Dr. Hoyo said.

“Somewhere along the line, some black women may be getting dropped because they don’t have the HPV subtypes that are considered to be most aggressive,” she summarized.

Her advice to clinicians with black females who have HPV infection and CIN is: “Broaden the subtypes that you look at.”

Currently, there is a vaccine in phase 3 clinical trials that targets 9 HPV subtypes (6, 11, 16, 18, 31, 45, 52, and 58). That means that 2 of the 4 most common subtypes in blacks are targeted by the experimental vaccine.

“We need more African American women to enroll in trials like this to see how beneficial this new vaccine will be for them,” Dr. Hoyo said.

The new study is not the first to indicate that black women have lower rates of HPV 16 and 18.

A recent report found that black race was a predictor of lower HPV 16 and 18 positivity among women with high-grade cervical lesions (Cancer. 2013;119(16):3052-3058).

However, the new study from the Duke team is the first to indicate that this race-influenced distribution of HPV subtypes also occurs in lower-grade cervical lesions. The Duke investigators also looked at high-grade lesions (CIN2/3).

In CIN2/3, HPV 16, 18, 33, 39, and 59 were the most common genotypes detected in white women, whereas HPV 31, 35, 45, 56, 58, 66, and 68 were the most prevalent in African American women.

12th annual International Conference on Frontiers in Cancer Prevention Research: Abstract B11, presented October 28. The study was supported by the National Institute of Health. The authors have disclosed no relevant financial relationships.

Vaccines Do Not Cover Most Common HPV Types in Black Women
Nick Mulcahy, Medscape Medical News, WebMD, Oct 28, 2013.
http://www.medscape.com/viewarticle/813365_print
1 of 2 06/03/2014 21:42

This is an urgent important message to warn you and all your state medical personnel including government and private officers, commissioners, and public health officials that the on-going HPV vaccines is not effective against the  cervical cancer in black women.

The HPV vaccines  Gardasil covers 6, 11, 16, 18, while Cervarix covers 16, 18.
For whites with cervical cancer (CIN1)  the most frequent HPV subtypes  were 16, 18, 56, 39, and 66.
But for blacks with CIN1, the most frequent HPV subtypes were 33, 35, 58, and 68.
Thus, in blacks, the most common genotypes were not HPV 16 and 18, which defies conventional wisdom about HPV infection.
In CIN2/3, HPV 16, 18, 33, 39, and 59 were the most common genotypes detected in white women, whereas HPV 31, 35, 45, 56, 58, 66, and 68 were the most prevalent in African American women.

The report in October 2013, by Hoyo et al, from Duke University sponsored by the National Institutes of Health of the United States, supports the finding published by another group in October 2013, (Cancer. 2013;119(16):3052-3058).
Therefore the use of Gardasil and Cervarix for prevention  of cervical cancer in Nigerians is not justified and totally ineffective.

Moreover, another work hereby attached [see below], published in Food Chem Toxicol. 1993 Mar;31(3):183-90, was the first to show that the solvent Tween 80 or Polysorbate 80 used for both Gardasil and Cervarix cause infertility; since then, human observations have confirmed fears of this outcome and billions of USD claims have been filed in the USA, UK and Japan. Please protect your children, protect your state, stop this HPV vaccination that does not make medical sense and puts your own children at risk. The Bill Gates sponsored 2.4 million doses was meant to yield 2.4 million infertile couples that would need IVF derived ovarian eggs for sale to Western Biotechnology firms for Embryonic Stem Cell Research.
Please Act now to inform your state commissioners of health and public health officials…
Academician Prince Dr Philip Njemanze MD.

PRESS RELEASE BY THE GLOBAL PROLIFE ALLIANCE (GPA) ON HPV VACCINE
At Press Briefings Organized by the Foundation for African Cultural Heritage on Monday 10th March, 2014 at TerraKulture Victoria Isl

and, Lagos.
Ladies and Gentlemen of the Press, today on 1st March 2014, the quarterly meeting of the Council on Global Health of the Global Prolife Alliance was held on web conferencing. Among the issues discussed, is a review of the rationale for vaccination of Nigerian children with the human papilloma
virus (HPV) Vaccine Gardasil under the Nigeria’s Cancer Plan of the Federal Ministry of Health (FMoH).

A NEW GROUND-BREAKING STUDY IN THE United States suggests the HPV vaccines given in Nigeria would not work for Nigerians.

The HPV subtypes that are most common in black women in the United States are not targeted by the currently available vaccines Gardasil and Cervarix, according to new research.
The findings suggest that current HPV vaccination will be less beneficial for black women in the US than for their white counterparts, said study coauthor Catherine Hoyo, PhD, MPH, of Duke University, in Durham, North Carolina. Persistent infection with HPV 16 and/or HPV 18 accounts for about 70% of all cervical cancers, said Dr. Hoyo. These are the subtypes targeted by Gardasil and Cervarix. Gardasil also targets HPV 6 and HPV 11. For whites with cervical cancer, the most frequent HPV subtypes were 16, 18, 56, 39, and 66. But for blacks with cervical cancer, the most frequent HPV subtypes were 33, 35, 58, and 68. Thus, in blacks, the most common genotypes were not HPV 16 and 18, which defies conventional wisdom about HPV infection.

According to the FMoH, the Nigerian Cancer Plan targets girls 9-15 years old, to ensure that they develop primary immunity against the HPV, the causative agent of herpes which has been primarily linked to cervical cancer. In the first phase 2008-2013, several thousands of Nigerian girls were
already vaccinated according to the National Coordinator Dr Patience Osinubi, speaking on-behalf of the FMoH.
The HPV vaccines to be used include Gardasil and Cervarix, both would have similar safety profiles for the purposes of this review.
We hereby review the medical science and rationale for the program for vaccination with HPV vaccine Gardasil and outline the health risks associated with this approach for Nigerians and others around the world.

Cervical Cancer in Nigeria
In Nigeria, population-based prevalence of abnormal cervical cytology has been studied. In one study, in Ibadan, Nigeria by Thomas JO et al Acta Cytol 2012, 56(3): 251-8, the authors revealed invasive cancer in 0.18% and the pre-cancer stages of high-grade squamous intraepithelial lesions (HSIL) (1.54%), atypical glandular cells (1.99%) and low grade (3.89%). Detection of the pre-cancer stages could be done very early using a simple test called the Papanicolaou smear or simply called Pap smear

In the United States, according to the Centers for Disease Control (CDC), the HPV is the most common sexually transmitted disease. More than 6 million women contract it annually, yet cervical cancer claims less than 3,900 women – most of which are due to not getting regular Pap smears.
In the United Kingdom, cervical cancer claims a mere 400 lives per year. As long as women get regular PAP smears, cervical cancer can be caught in its early, and easily treatable, stages. Despite the high prevalence rates of cervical cancer mortality is low because of the strong immune system, which according to the CDC clears the infection by more than 90% cases.

PROBLEMS WITH HPV VACCINES IN UNITED STATES AND JAPAN
The United States Federal Government’s Vaccine Adverse Events Reporting System (VEARS) has received over 9,000 reports of problems since the vaccine’s introduction in 2006, which include at least 28 spontaneous abortions, and 7 deaths.

The Japanese government had decided to withdraw its support for the HPV vaccine schedule. This decision came after the government received approximately 2000 reports from women and girls suffering adverse reactions, including long-term pain, numbness, paralysis and infertility.
http://www.naturalnews.com/041099_gardasil_side_effect_japan_infertility.htmlHP

The GPA Council posed the following questions: Why is the HPV vaccine being pushed so vigorously by the so-called development agencies, WHO and Bill and Melinda Gates foundation, when:
1. the HPV vaccine prevents a type of cancer that is very rare in Nigerian women and the vaccine is practically ineffective in the subtypes that occur among black women
2. the HPV vaccine protects against a virus that in 98% of case, is not the cause of cervical cancer
3. the HPV vaccine prevents a type of cancer that can be easily caught and treated by promoting regular gynecological exams and Pap smear tests
4. the HPV vaccine is promoted to girls years before becoming sexually active, even though the vaccine may only offers no protection for Nigerian girls
5. the HPV vaccine offers less protection than what promotion of safe sex practices could accomplish. Abstinence before marriage thought in schools to children would achieve 100% protection.
According to an article in New England Journal of Medicine  (http://content.nejm.org/cgi/content/full/354/25/2645 ) condoms though less effective is at 70%, and is by FAR a better protection than Gardasil, for example.
6. the HPV vaccine prevents just 4 strains that are not frequent among Nigerians and black women in general, out of more than 100 strains of HPV; all of which the immune system can clear up on its own in 90% of all cases anyway
7. the HPV vaccine has NOT been proven safe. No one knows if it can cause cancer or infertility, for example

The Global Alliance for Vaccine and Immunization (GAVI) Cost-cutting on Vaccine Price for World Population Control

The GAVI is another non-governmental organization with close ties to the Bill and Melinda Gates foundation, charged with the task of globally driving the use of the HPV vaccine among others into national health policies of developing countries with the ‘hidden agenda’ of using vaccines for worldwide population control. To accomplish this task, GAVI has announced a new record low price for the HPV vaccines to enable millions of girls in developing countries get so-called ‘protection’ against the virus.

From 2013-2017, according to the new price regime, Merck, a U.S. drug-maker expects to supply around, 2.4 million doses of its Gardasil at $4.50 per dose to GAVI-eligible 10 countries for HPV (List of countries and Population Growth rate: Niger – 3.84%, Tanzania – 3.04%, Malawi – 2.86, Madagascar – 2.8, Kenya – 2.7, Zimbabwe – 2.7, Mozambique – 2.5, Lao PDR – 2.5%, Ghana 2.17, Sierra Leone – 1.91%) (http://www.gavialliance.org/ ) while the British company, GlaxoSmithKline’s (GSK) Cervarix would cost $4.6 per dose.

Nigeria (Pop. Growth rate: 2.79%) is seen as wealthy with oil-based economy to purchase the vaccine at a cost of $30-$40. The impact on population reduction by this singular GAVI intervention using HPV vaccine could be as high as 20 million less Africans would be born in these Sub-saharan African countries.
This is an effect only comparable to ten-fold effect of Hiroshima atomic bomb on Africa!

The only outcome is infertility of our Nigerian women, who will now go the IVF Clinics for the ovarian eggs to be pouched and sold to Biotech companies who will kill their children in Western labs for embryonic stem cell research!

Bill Gates and associates own 90% of the Biotech Companies into embryonic stem cell research industry, estimated to boost Western Economy to the tune of 30 Trillion USD if they succeed to use Nigerians as ‘Guinea Pigs’ to perfect the crucial technology of Somatic Cell Nuclear Transfer (SCNT) a therapeutic organ cloning procedure. What a paradox conditioned by ignorant and c

orrupt governance!

A careful study of the GAVI eligible countries for HPV, 90% plus Nigeria are the top Black Sub-Saharan African countries with the fast-pace growing population in the World, so they MUST BE STOPPED by stilt HPV vaccination for population control and ovarian egg pouching!

WHO ELSE IS TARGETED?
The HPV vaccine Gardasil is in the list of vaccinations that all female migrants ages 11 to 26 years MUST get before they can obtain GREEN CARD!

ANTI-FERTILITY VACCINES
As we promised in our last press briefing, we will also provide you some update reports on the status of development of infertility vaccines for worldwide population control that, our observers around the World have been monitoring.

In PUBMED database on the Internet there are over 50 research papers on works on new “contraceptive vaccines’ funded by WHO, Bill and Melinda Gates Foundation, Rockefeller Foundation and others, so-called development international partners. They state as the main goal (FASEB Journal 1993) to find a vaccine “which should be relevant to world-wide regulation of population growth”.

There are two broad categories of infertility vaccines: First, by toxic effects against the reproductive organs, usually used as base solvents such as Polysorbate 80 or Tween 80, in HPV vaccines, as well as solvents in cosmetics for women exported to Africa! The second, are antibodies hormones of pregnancy – Human Chorionic Gonadotropin (hCG) attached to a conventional vaccine like tetanus vaccine.

The Dangers of HPV vaccine Solvent – Polysorbate 80/Tween 80
Polysorbate 80, also called Tween 80, is a detergent (surfactant) used to deliver certain drugs or
chemical agents across the blood-brain barrier.
The HPV vaccine and season’s flu vaccine made by GlaxoSmithKline, called Fluarix, contains polysorbate 80, as does Novartis’ Agriflu.
The HPV vaccine, Gardasil, and a number of other childhood vaccines that carry the potential for serious side effects also contain polysorbate 80.
The scientific study on polysorbate 80 was done by Slovakian scientists and published in the journal Food and Chemical Toxicology in 1993.
(http://www.ncbi.nlm.nih.gov/pubmed/8473002?dopt=Abstract)

The researchers injected female rats with Tween 80 (in 1, 5 or 10 percent aqueous solution), on days four through seven after birth. They discovered that Tween 80 accelerated the rats’ maturation, prolonged the estrous cycle, decreased the weight of the uterus and ovaries, and caused damage to the lining of the uterus indicative of chronic estrogenic stimulation. The rats’ ovaries were also damaged, with degenerative follicles and no corpora lutea (a mass of progesterone-secreting endocrine tissue that forms immediately after ovulation).

Such severe deformities to the ovary can lead to infertility.
The question is whether or not these effects also apply to humans. The answer is simply, we do not know at this time and no clear research has been demonstrated.
Certainly, Nigerian children would not like to volunteer themselves as test subjects to demonstrate that these grave dangers may or may not apply to humans.

Dangers of L-histadine and Squalene in Gardasil
Gardasil also contains L-histadine, and histamines have been found to increase clot production fivefold when combined with surfactants. L-histidine can also pass through the placenta to the fetus.

This may explain why death from blood clots within hours or days is the MOST COMMON form of death after receiving Gardasil.
You can also find this ingredient in any vaccine using the adjuvant MF59, which contains both polysorbate 80 and squalene, which is yet another hazardous ingredient. Squalene is an adjuvant used in vaccines marketed in Europe and other countries, but squalene has not yet been approved by the FDA as an ingredient for vaccines distributed in the United States.

ANTI-HCG VACCINES
In 1993 a journal article published in the British Medical Bulletin, anti-fertility vaccines were being engineered “incorporating tetanus or diphtheria toxoid linked to a variety of human Chorionic Gonadotropin (hCG) based peptides.”
(http://hinari-gw.who.int/whalecombmb.oxfordjournals.org/whalecom0/cgi/content/abstract/49/1/88 )

The vaccine is to prevent the maternal recognition of pregnancy by inducing a state of immunity against hCG, the hormone that signals the presence of embryo to the maternal endocrine system.

Free tetanus vaccines sponsored by Bill and Melinda Gates Foundation and offered by WHO to young women of childbearing age for years in Tanzania, Nigeria, Mexico and the Philippines, were found to contain anti-hCG which causes spontaneous abortions if the woman becomes pregnant.
http://thinktwice.com/birthcon.htm

In 1997, another paper by G.P. Talwar titled Vaccines for Control of Fertility and Hormone Dependent Cancers was published by Immunology and Cell Biology.
http://www.nature.com/icb/journal/v75/n2/abs/icb199726a.html
anti-hCG anti-bodies are merged to tetanus vaccine and given as contraceptive vaccines to attack hCG and prevent pregnancy.

GLOBAL PROLIFE ALLIANCE (GPA) RECOMMENDATIONS ON HPV VACCINATION TO
AFRICAN COUNTRIES
1. The government of Nigeria and other African countries should follow the example by the Japanese government to withdraw from the HPV vaccination schedule based on the evidence of lack of safety of the HPV vaccine. The African countries must declare vaccination and immunization national security priorities closed to any foreign interventions, including from multi-lateral U.N agencies and donor partners. All donations and assistance must be in form of cash to make acquisitions through privately secured arrangements by the countries themselves. The United Nations’ General Assembly must declare as illegal any attempt to use vaccines for population control, such acts should be considered as Crimes Against Humanity.


2. HPV Vaccination would increase prevalence and mortality from Sexually Transmitted Diseases in girls from Nigeria and other African countries.
The vaccine based approach being adopted by the FMoH would be associated with even a much greater risk of death from sexually transmitted diseases like HIV, gonorrhea, Syphilis and even HPV. The HPV vaccine would only provide about three years of protection.

However, the teenagers would by cultural and social disposition due to lack of information declare a false sense of invincibility from sexually transmitted diseases and thus abandon safe-sex practices and abstinence. It would be expected that, infections with other sexually transmitted diseases including HIV/AIDS would rise dramatically, and deaths as well, among the HPV vaccinated.

3. In all developed countries who are still following the HPV vaccination schedule, the vaccines are given ONLY on doctor’s prescription after evaluating the patient for medical contraindications, for example clotting abnormalities and allergies. Failure to put the vaccine under doctor’s prescription would expose millions of Nigerians girls to severe health risks, moreover, the vaccine does not even work!

4. It must be noted that medical complications from the HPV vaccine could cost the Nigerian government several billions of naira in court awarded damages as is the case already in the United States cost close to $3 Billion USD. The public attention draw nby side effects of the HPV vaccine in the U.S. is also echoing in Nigeria.

Nigerians would soon know to hold the Federal government accountable for the health disabilities from the HPV vaccine, and the government may soon f

ace law suits with huge financial claims. Meanwhile, the damage is done to our entire population by GAVI, drugmakers and the so-called development partners, who would not incur any legal costs, since the vaccines were given by the Federal government without specific doctor’s prescription as recommended by the manufacturers!

5. In Nigeria, the Cancer Plan of the FMoH would only be meaningful for women, if it hinges on early detection of cervical cancer in women in both urban and rural communities. The introduction of the HPV vaccine would not impact significantly on the disease prevalence, mortality and morbidity and hence must be abandoned.

6. The National Agency for Food and Drug Administration and Control (NAFDAC) should exercise her regulatory authority to stop all HPV vaccinations and undertake safety monitoring of all reports from those already vaccinated. A Nigerian Vaccine Adverse Events Reporting System (NIVEARS) should be established for all vaccines and a toll free number as well as web-based forms should be made available. The already established drug side effect reporting should be implemented for the HPV vaccine given. The public should be educated on signs and symptoms to look for in each vaccine category. Both State and Federal Legislature should impose a moratorium and administration of the HPV vaccine until all studies are completed over the next five years. All administrations of HPV vaccine must be under strict doctor’s prescription, as it is in every other country of the world. Similarly, all cosmetics containing Polysorbate 80/Tween 80 should be banned for use in Nigeria because on the uncertain side effects on fertility.

ALERT! The HPV vaccinations have commenced in all States in Nigeria!
Signed:  Academician Prince Dr Philip C. Njemanze MD
Chairman, Global Prolife Alliance (GPA) for the Health Council on National Policies

Copies sent to: National Press, International Press, National Parliaments, AU, EU Parliament, U.S. Congress, Nigeria
National Assembly, President of the Federal Republic of Nigeria, Ministers of the Federal Republic of Nigeria, Heads of
States, UN Ambassadors, Bishop Conferences, Human Rights Organizations, UN Agencies, prolife groups and others.