Cytomegalovirus (CMV) — A herpes infection that causes serious illness in people with AIDS. CMV can develop in any part of the body but most often appears in the retina of the eye, the nervous system, the colon or the esophagus. [American Social Health Association, http://www.ashastd.org/learn/learn_glossary_A_D.cfm]
Knowledge and Practices of Obstetricians and Gynecologists Regarding Cytomegalovirus Infection During Pregnancy — United States, 2007
In the United States, congenital cytomegalovirus (CMV) infection occurs in approximately 1 in 150 live births (1), leading to permanent disabilities (e.g., hearing loss, vision loss, and cognitive impairment) in approximately 1 in 750 live-born children (2).
A common mode of CMV transmission to a pregnant woman is through close contact with infected bodily fluids such as urine or saliva, especially from young children (3). Because no vaccine is available and treatment options are limited, renewed attention has been given to prevention of CMV infections among pregnant women through traditional infection-control practices, such as good hand hygiene (3).
These practices have been encouraged by organizations such as CDC and the American College of Obstetricians and Gynecologists (ACOG) (4), which recommend that obstetricians and gynecologists (OB/GYNs) counsel women on careful handling of potentially CMV-infected articles, such as diapers, and thorough hand washing after close contact with young children (Box).
Despite this increased emphasis on avoiding infection during pregnancy, few women are aware of CMV infection and how it can be prevented (5).
During March–May 2007, ACOG surveyed a national sample of OB/GYNs to assess their knowledge and practices regarding CMV infection prevention. This report describes the results of that survey, which indicated that fewer than half (44%) of OB/GYNs surveyed reported counseling their patients about preventing CMV infection. These results emphasize the need for additional training of OB/GYNs regarding CMV infection prevention and for a better understanding of the reasons that physician knowledge regarding CMV transmission might not result in patient counseling.
In March 2007, ACOG mailed surveys to members of the ACOG…Physicians were asked about their knowledge and practices related to prevention of several infections, including CMV, during pregnancy…
Although 90% of OB/GYNs reported knowing that washing hands reduces the risk for CMV infection during pregnancy, a smaller proportion were aware that not sharing utensils (57%) and avoiding children's saliva (55%) reduces infection risk (Table 2).† Sixty percent of OB/GYNs reported that they routinely recommended hand washing to pregnant women; approximately one third reported routinely recommending that pregnant women not share utensils and avoid child saliva (31% and 30%, respectively)…
Approximately one fourth (27%) of OB/GYNs reported having diagnosed CMV infection in a pregnant woman since 2003 (Table 2).
Among the 86% of OB/GYNs who reported ever testing for CMV during pregnancy, most provided CMV testing only if their patients requested a test…CMV testing during pregnancy should be performed under certain circumstances, which include the development of a mononucleosis-like illness during pregnancy.¶
Congenital CMV infection is a major source of childhood disability, including hearing loss, vision loss, and cognitive impairment (2). The estimated 5,000–8,000 children per year who develop disabilities associated with CMV infection is similar to or higher than the number estimated to be affected by better-known conditions, including Down syndrome and neural tube defects (2,3).
Women who experience their first (i.e., primary) infection during pregnancy are at highest risk for transmitting CMV to their fetuses, with approximately 33% of fetuses becoming infected. However, women who have experienced an infection before pregnancy and then have a recurrent infection (i.e., a viral reactivation or reinfection with a different strain) during pregnancy also can transmit CMV to their fetuses, with approximately 1% of fetuses becoming infected (1).
Most infections among pregnant women are believed to occur through contact with the urine or saliva of infected children or through sexual activity (6).
Numerous potential interventions exist for preventing congenital CMV infections or disease. Several vaccines are being developed, although progress has been slow (3). The effectiveness of certain interventions is controversial, including antiviral treatment or passive immunization using hyperimmune globulin for pregnant women with primary CMV infection (7) and antiviral treatment for newborns with congenital infection (8). Other types of interventions, such as newborn screening and follow-up to identify developmental disabilities and improve language or educational development, target secondary outcomes.
Good hand hygiene is a simple intervention that has the potential to decrease risk for CMV infection during pregnancy (3,4).
CMV frequently is found in the urine and saliva of preschool-age children (typically 5%–25% of young children, although the percentage can be higher in day care centers) (3) and has been found on the hands of child-care providers.
Furthermore, hand washing has been shown to prevent infection with various pathogens. Thus, although no definitive studies have documented that particular interventions reduce transmission, evidence suggests that avoiding exposure to urine and saliva, especially through good hand hygiene, reduces risk for CMV infection during pregnancy (3).
Although such behavioral changes can be difficult to initiate and maintain, evidence indicates that pregnant women will make certain behavior changes that will protect their [offspring] (3). Such measures are simple and likely to be cost effective; good hand hygiene is inexpensive, and the cost savings from preventing even one case of congenital CMV disease is high (9).
CMV can be transmitted through sexual contact, which is important for women to know. Because of the numerous programs and resources already in place to promote healthy…sexual practices for infections other than CMV (e.g., existing HIV/AIDS programs), this survey of OB/GYNs focused on prevention messages that might not be as widely promoted during pregnancy, such as good hand hygiene.
Whether OB/GYNs should routinely test pregnant women for CMV is a complicated matter. An initial negative maternal immunoglobulin G (IgG) test, which indicates that the woman has never been infected with CMV, might indicate a higher risk for fetal infection if the mother subsequently becomes infected during pregnancy and thus might be a useful motivational tool to encourage the mother to practice good hygiene.
A positive maternal IgG test might indicate lower risk for fetal infection; nevertheless, good hand hygiene still should be advised to prevent possible maternal CMV reinfection…because no proven treatment exists, routine CMV testing during pregnancy is not recommended; testing is recommended only when a fetal anomaly is detected, a pregnant woman experiences a mononucleosis-like illness, or a pregnant woman requests the test…
1. Kenneson A, Cannon MJ. Review and meta-analysis
of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol 2007;17:253–76.
2. Dollard SC, Grosse SD, Ross DS. New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. Rev Med Virol 2007;17:355–63.
3. Cannon MJ, Davis KF. Washing our hands of the congenital cytomegalovirus disease epidemic. BMC Public Health 2005;5:70.
4. American College of Obstetricians and Gynecologists. Perinatal viral and parasitic infections. ACOG Practice Bulletin 20. 20th ed. Washington, DC: American College of Obstetricians and Gynecologists; 2000.
5. Jeon J, Victor M, Adler S, et al. Knowledge and awareness of congenital cytomegalovirus among women. Infect Dis Obstet Gynecol 2006;2006:80383.
6. Fowler KB, Pass RF. Risk factors for congenital cytomegalovirus infection in the offspring of young women: exposure to young children and recent onset of sexual activity. Pediatrics 2006;118:e286–e92.
7. Nigro G, Adler SP, La Torre R, Best AM. Passive immunization during pregnancy for congenital cytomegalovirus infection. N Engl J Med 2005;353:1350–62.
8. Kimberlin DW, Lin CY, Sanchez PJ, et al. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr 2003;143:16–25.
9. Institute of Medicine Committee to Study Priorities for Vaccine Development. Vaccines for the 21st century: a tool for decision making. Washington DC: National Academies Press; 2000.
10. Revello MG, Gerna G. Pathogenesis and prenatal diagnosis of human cytomegalovirus infection. J Clin Virol 2004;29:71–83.
** Wash hands often with soap and water, especially after contact with saliva of or diapers from young children. Wash well for 15-20 seconds.
** Do not kiss children aged <6 years on the mouth or cheek. Instead, kiss them on the head or give them a hug.
** Do not share food, drinks, or utensils (spoons or forks) with young children.
** advise careful handling of potentially infected articles, such as diapers.
** advise thorough handwashing when around young children or immunocompromised persons.
** explain that careful attention to hygiene is effective in helping prevent CMV transmission.
*available at http://www.cdc.gov/cmv
[CDC, MMWR Weekly, January 25, 2008 / 57(03);65-68; http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5703a2.htm?s_cid=mm5703a2_e]