Subsequent Risk of Metabolic Syndrome in Women With a History of Preeclampsia

Chinese Study Data From the Health Examinees Study [Comment: An American researcher has made this notation: “I would caution against a causal interpretation here as implied in the study’s bottom line: Specifically, the very same factors that lead to late age at FFTP, (i.e., subfertility), may be responsible for pre-eclampsia and downstream metabolic syndrome, diabetes, etc. I believe future research will link all these conditions back to glycine deficiency and the chronic metabolic inflammation it causes.” 17 July 2015] Introduction: Preeclampsia is one of the most common complications of pregnancy. This pregnancy-specific syndrome, characterized by new-onset hypertension along with proteinuria during gestation, occurs in approximately 3%–8% of all pregnancies worldwide.1 Preeclampsia is generally regarded as a disease of the first pregnancy, but it frequently recurs in later pregnancies.2–4 Preeclampsia increases the risk of maternal mortality, as well as neonatal morbidity and/or mortality.1,5 Furthermore, compelling evidence indicates that the long-term effects of preeclampsia are associated with an increased risk of cardiovascular disease in later life. Previous studies have suggested that preeclampsia is associated with pathophysiological abnormalities, including endothelial dysfunction and systemic hypertension, and metabolic disorders, such as obesity, insulin resistance, hyperglycemia, and diabetes mellitus.3,6,11–14 The occurrence of a cluster of these perturbations in multiple metabolic pathways is generally known as metabolic syndrome, a condition that is assumed to create a milieu leading to increased risk of cardiovascular disease.15 This means that preeclampsia can increase the risk of metabolic syndrome, which may be an ascendant event of future cardiovascular disease… Results: … Women diagnosed with preeclampsia tended to be older at first pregnancy (25.4 years vs 24.9 years) and have higher...