Repeated Mifepristone Abortion Affects Subsequent Pregnancy Outcomes in BALB/c Mice (2012)

This 2012 MOUSE study from China shows that chemical abortion mifepristone (RU-486) adversely affects the female reproductive system. Overall, mice that experienced 2 previous medical/chemical abortions had spontaneous abortions (‘miscarriages’) in subsequent pregnancies; repeated medical/chemical abortion affected the expression of metabolic genes in the livers of living offspring; abortion decreased sperm motility in the first generation male offspring; and finally, medical/chemical abortion caused reduced reproductive capacity, caused placental dysfunction, and reduced the expression of protein-making genes needed in pregnancy metabolism. It should be noted that no spontaneous abortions (miscarriages) were observed in the control groups of mice.   http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0048384&representation=PDF Abstract Aim: In this study, we aimed to establish a mouse model of repeated medical termination of pregnancy in order to determine subsequent outcomes. Methods: A model of mifepristone (RU 486)-induced medical abortion was established in BALB/c mice to facilitate the investigation of the impact of medical abortion on subsequent pregnancies, including litter sizes and newborn birth weights. Pregnant mice were sacrificed to… – examine midterm pregnancy status, investigate the frequency of fetal resorption, – measure placental function gene expression by real-time PCR and immunohistochemistry. Offspring liver mRNA was harvested for real-time PCR to determine gene expression and assess the effects of abortion on offspring development. Results: Mice subjected to 2 previous medical abortions experienced spontaneous abortions in subsequent pregnancies. Medical abortion caused reduced reproductive capacity and affected placental dysfunction, with reduced expression of tissue factor (TF) and genes encoding proteins involved in metabolic functions relevant to pregnancy, such as 11b-hydroxysteroid dehydrogenase 1/2 (11b-HSD1/2) and glucocorticoid receptor (GR). Reduced expression was also observed for platelet endothelial cell adhesion molecule-1 (CD31)...

February 2012: Abortion

  FIND PAST HOMEPAGE TOPICS UNDER "CURRENT HEADLINES" IN THE LEFT MENU…  National Marriage Week February 7-14, 2012 Hippocratic Medicine means to DO NO HARM Women Do Not NEED Abortion Women have the RIGHT TO KNOW about the Abortion – Breast Cancer CONNECTION  AND the Connection of Abortion to Subsequent Preterm Birth, Cerebral Palsy/ ASD Our Choices Expose our Values… Refuse to Choose Abortion… Genuine CHOICE Requires Real OPTIONS                  Occupy the Womb  (SBA List) Abortion Business Workers: Report Problems —  http://clinicworker.com/ Resource: Archives of the American Holocaust — http://www.lifedynamics.com/library/ Books, writings, documents, and other materials from the Anti-Life advocates, 1917 – Present   Abraham Lincoln said-  'It is never right to do the wrong thing!' Past time to DEFUND PP…   The Inherent Racism of Population Control — http://www.lifesitenews.com/waronfamily/Population_Control/Inherentracism.pdf   40 Days for Life International Campaign 22 February – 1 April 2012   www.40daysforlife.com   Alliance for Post-Abortion Research and Training — www.standapart.org Fatherhood Begins in the Womb –http://www.toomanyaborted.com/?page_id=4009 www.imagesofabortion.com   Truth Booth — A Window to the Womb — http://www.truthbooth.org/   Same Old 'Abortion Safer Than Childbirth' Mantra Spews Inaccuracy & Confusion… GET THE FACTS! Confront Abortion Errors With Truth Study Claiming Abortion Safer Than Birth Used Faulty Data Is Violating the 1947 Nuremberg Code in Canada Ethical? Open Letter to Dr. Dan Reilly Abortion Businesses in New Mexico With No Regulatory Oversight Injure Women Refuting the Claim Women Will Resort to Coat Hanger Abortions Practitioner Settles Case of Woman Killed in Failed Abortion Abortion Business in Illinois Killed Patient in Failed Abortion, Didn’t Perform CPR… Much More… Notorious Rockford, Illinois, abortionist Christensen frequenting Planned Parenthood in Madison,...